England was relatively slow to begin settlements in North America, which stood small in the shadow of the vast Spanish Empire. Several halting attempts were made during the 1500s, most notably those of Sir Humphrey Gilbert and Sir Walter Raleigh. No settlements resulted from those early ventures and widespread interest in colonization did not begin to build until after the defeat of the Spanish Armada in 1588. The humiliation of Spanish power on the Atlantic brought a new confidence to English investors and adventurers.

In 1606, King James I divided Virginia between two groups of competing English merchants. Their charters proclaimed their intentions to spread Christianity, but in truth the primary motivation was the lure of gold and silver.

The Virginia Company of Plymouth was granted rights to the northern part of Virginia between 38º and 45º north latitude. This group made a feeble attempt at a settlement on the Kennebec River in what would later become Maine, but the tiny colony lasted only a few months.

The Virginia Company of London, however, was better prepared to act on its rights to those lands between 34º and 40º north latitude, the southern part of Virginia. The fact that the chartered areas overlapped one another placed a special premium on speed. Under the command of Captain Christopher Newport, the London group dispatched three ships, theGodspeed, the Discovery and the Susan Constant. Departing in December 1606 and arriving in Chesapeake Bay in May of the following year, the ships brought 144 ill-prepared settlers to the New World.

A site was selected on a peninsula that jutted into a river. Prudently, the leadership named both the town and the river for their benefactor, James I. Less prudently, they selected a low-lying area that was prone to high humidity and hosts of mosquitoes. The isolated location did, however, provide an easily defended position in the event of Indian attack.

Jamestown's early history alternated between near disaster and faint success. The root difficulty was that the colony needed soldiers, craftsmen and farmers, but instead was populated largely by self-important gentlemen unaccustomed to manual labor. Energy was wasted in the search for gold and silver, when prudence demanded crop planting.

The consequences of such actions were severe. More than one-third of the colonists died during the winter of 1607-08, having fallen prey to malaria, typhoid fever, scurvy, and dysentery. The health crisis was compounded by bitter leadership feuds within the shrinking community.